解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Malignant gastrointestinal neuroectodermal tumors (GNETs) are rare aggressive malignant neoplasms that exclusively occur within the wall of the gastrointestinal tract. The GNET was first described as an 'osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma (CCS) of soft parts...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10060
更新日期:2019-04-01 00:00:00
abstract::Ovarian cancer (OC) is the most common and lethal gynecologic malignancy. The pathophysiology of OC tumor development is complex and involves numerous biological pathways. Previous studies suggest that circular (circ)RNAs serve important roles in OC tumor pathology. In the present study, a re-annotation strategy was p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10021
更新日期:2019-04-01 00:00:00
abstract::Renal collecting duct carcinoma (CDC) is a rare and highly aggressive subtype of kidney cancer with poor prognosis. We report a case of one patient, who was successfully treated with gemcitabine-platin based chemotherapy for polymetastatic renal CDC, and experienced a late and prolonged complete remission. In June 201...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9991
更新日期:2019-03-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a serious threat to human health. Chemotherapy drugs such as cisplatin are widely used in cancer treatment, but can cause severe side effects. Hydroxyl safflower yellow A (HSYA) is a water-soluble chalcone glycoside substance extracted from safflowers (Carthamus tinctorius L.) that ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9946
更新日期:2019-03-01 00:00:00
abstract::Increasing number of microRNAs (miRNAs) have been reported to play an important role in the development and progression of non-small cell lung cancer (NSCLC). In particular, microRNA-497-5p (miR-497-5p) has been proposed as a tumor suppressor miRNA in human cancers. However, the role of miR-497-5p and its potential mo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9954
更新日期:2019-03-01 00:00:00
abstract::The present study aimed to examine whether serum microRNA (miR)-22 may be considered a potential biomarker to differentiate patients with papillary thyroid cancer (PTC) from healthy controls. Reverse transcription-quantitative polymerase chain reaction demonstrated that serum miR-22 expression was significantly enhanc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10011
更新日期:2019-03-01 00:00:00
abstract::Hyperbaric oxygenation (HBO) on postoperative rehabilitation of brain tumors and effects on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were explored. A retrospective analysis of 132 patients with brain tumors treated in the People's Hospital of Rizhao from October 2014 to October 2017 was performe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10000
更新日期:2019-03-01 00:00:00
abstract::Activation of brown adipose tissue (BAT) is an effective strategy for treating obesity. Hepatocellular carcinoma (HCC) is a life-threatening hepatic malignancy with a high mortality rate. Considering that obesity is a risk factor for HCC, the aim of the present study was to investigate the association between HCC and ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9977
更新日期:2019-03-01 00:00:00
abstract::Glycocholic acid (GCA) is a novel identified biomarker for hepatocellular carcinoma (HCC). However, clinical pathological study of GCA has not been extensive due to the limited availability of anti-GCA monoclonal antibodies (mAbs) and restricted detection methods. In the present study, using human GCA conjugated with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9943
更新日期:2019-03-01 00:00:00
abstract::The aim of this study was to investigate the effect of dexmedetomidine (Dex) on the respiratory function during anesthesia induction in pediatric patients undergoing retinoblastoma (RB) resection. A total of 87 pediatric patients who underwent RB resection in Yidu Central Hospital of Weifang were recruited into this s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9893
更新日期:2019-03-01 00:00:00
abstract::Pristimerin is an active compound isolated from the traditional Chinese herbs Celastraceae and Hippocrateaceae. It has been reported to exert antitumor effects under experimental and clinical conditions; however, the antitumor effects and underlying mechanisms of pristimerin in oral cancer cells have not yet been iden...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9903
更新日期:2019-03-01 00:00:00
abstract::MicroRNAs (miRNAs/miRs) are small, noncoding RNA molecules that are closely associated with the occurrence and development of tumors. miR-20b is overexpressed in hepatocellular carcinoma cell lines and tissues. However, it is not clear whether miR-20b can promote the proliferation of hepatocellular carcinoma cells. In...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9925
更新日期:2019-03-01 00:00:00
abstract::In the current era of multi-disciplinary treatment, precise and detailed diagnosis prior to treatment is crucial for clinical practice. For different lesions that fit different indications, the optimum approach for treatment differs significantly. Thus, the recent 8th American Joint Committee on Cancer classification ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9920
更新日期:2019-03-01 00:00:00
abstract::The aim of the present study was to investigate the ability of Nimotuzumab to increase radiosensitivity at different delivery times in the mixed cancer cell line Eca109, to determine the optimal delivery time. Cultured Eca109 cells were classified into five groups: Control with no treatment (O group); irradiation with...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9897
更新日期:2019-03-01 00:00:00
abstract::Despite improvements in diagnosis and treatment, the survival of patients with advanced stages of esophageal squamous cell carcinoma (ESCC) remains poor. Therefore, novel biomarkers that can assist with early detection of ESCC are required. In the present study, three paired ESCC and normal esophageal tissue samples f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9904
更新日期:2019-03-01 00:00:00
abstract::Being biomarkers that reflect host nutritional and immune status, prognostic nutritional index (PNI) and neutrophil/lymphocyte ratio (NLR) have been identified to be independent prognostic factors in various malignancies. The aim of the present study was to determine the predictive value of these parameters for the pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9870
更新日期:2019-02-01 00:00:00
abstract::Effective therapies are limited for pancreatic cancer, particularly for those with distant tumour metastases. Therefore, more individualised drug screening is urgently required. Next-generation sequencing (NGS) is a powerful tool to investigate the genomic landscape of patients and the mechanism of drug response, whic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9876
更新日期:2019-02-01 00:00:00
abstract::The aim of the present study was to investigate the function of microRNA-543 on liver cancer cell proliferation and apoptosis, and also to identify whether the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway was a direct target of microRNA-543. When compared with para...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9838
更新日期:2019-02-01 00:00:00
abstract::Endotracheal intubation (ETI) and laryngeal mask airway (LMA) in terms of hemodynamics and reaction were compared. A total of 54 general anesthesia patients were randomized into two groups with 27 cases in each group. Acceleration index (ACI), cardiac index (CI), cardiac output (CO), left cardiac work (LCW), systemic ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9813
更新日期:2019-02-01 00:00:00
abstract::Lung cancer is one of the leading causes of cancer-associated mortality. C-reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as general parameters for systemic inflammatory response (SIR). Fu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9858
更新日期:2019-02-01 00:00:00
abstract::We previously reported that the dissected pancreatic tissue margin (DPM) and the preoperative serum level of carbohydrate antigen 19-9 (preCA19-9) were independent prognostic factors in pancreatic ductal adenocarcinoma (PDAC). In the current study, the prognostic relevance of these factors, including their molecular a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9839
更新日期:2019-02-01 00:00:00
abstract::Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Among them, BDNF is the m...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2018.9854
更新日期:2019-02-01 00:00:00
abstract::The prognosis for patients with head and neck cancer (HNC) remains poor, owing to uncontrolled tumor invasion and metastasis. Epithelial-mesenchymal transition (EMT) serves an important role in this invasion and metastasis, and transient receptor potential polycystic 2 (TRPP2) enhances metastasis and invasion by regul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9752
更新日期:2019-02-01 00:00:00
abstract::The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesion...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9788
更新日期:2019-02-01 00:00:00
abstract::Oncostatin M (OSM) induces the differentiation of liver cancer stem cells (LCSCs) and increases sensitivity to the chemotherapeutic agent 5-fluorouracil, whereas salinomycin (Sal) induces apoptosis in cancer stem cells and inhibits the proliferation of liver cancer cells. However, there have been no studies investigat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9796
更新日期:2019-02-01 00:00:00
abstract::Alcohol consumption is a risk factor for the development of hepatocellular carcinoma (HCC); however, the association between alcohol and HCC remains unknown. The present study aimed to identify key genes related to alcohol-associated HCC to improve the current understanding of the pathology of this disease. Alcohol-as...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9757
更新日期:2019-02-01 00:00:00
abstract::To determine the radiosensitizing effect of apatinib on esophageal cancer cells, and to preliminarily investigate the underlying mechanism, KYSE-150 cells were treated with apatinib, x-ray or apatinib combined with x-ray, and compared with a blank control. It was observed that apatinib significantly inhibited vascular...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9803
更新日期:2019-02-01 00:00:00
abstract::It is estimated that breast cancer will be the second leading cause of cancer-associated mortality in women in 2018. Previous research has demonstrated that the atypical protein kinase C-ζ (PKC-ζ) is a component of numerous dysregulated pathways in breast cancer, including cellular proliferation, survival, and cell cy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9792
更新日期:2019-02-01 00:00:00
abstract::The incidence of gastric cancer is high, especially in China. The present study aims to provide a novel therapeutic target for gastric cancer. Peripheral blood, cancerous and paracancerous tissues were collected from patients with gastric cancer. T-cell immunoglobulin mucin domain-3 (Tim-3) expression in T-cells was m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9743
更新日期:2019-02-01 00:00:00
abstract::We investigated whether treatment package time was significantly associated with survival outcomes of resectable locally-advanced laryngeal squamous cell carcinoma in patients who consecutively underwent various treatments, including surgery alone and salvage surgery for residual tumor. A total of 100 patients with cl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9664
更新日期:2019-01-01 00:00:00
abstract::An individual with a twin who has developed leukemia or non-Hodgkin lymphoma (NHL) has an increased risk of developing the same disease, particularly with monozygotic twins. The few reported pairs of twins who developed NHL had similar primary sites and pathological subtypes. Here, we present the first reported cases ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9723
更新日期:2019-01-01 00:00:00
abstract::SIRT6, is a member of the NAD-dependent sirtuin family of enzymes, and has been reported as a novel tumor suppressor gene or oncogene, dependent on the type of cancer. However, the role of SIRT6 in osteosarcoma has not been investigated. The present study demonstrated that the expression of SIRT6 was downregulated in ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9676
更新日期:2019-01-01 00:00:00
abstract::This study investigated whether microRNA-183 and microRNA-141 in nasopharyngeal carcinoma (NPC) lesions are potential risk factors for poor prognosis. A total of 317 NPC patients admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2010 to March 2015 were included. Reverse transcripti...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9650
更新日期:2019-01-01 00:00:00
abstract::Prostate cancer is the most common form of cancer in men, with increased incidence rates observed in older individuals. Prostate cancer is primarily driven via activation of the androgen receptor (AR), the principal transcriptional factor governing prostate cancer cellular programming and its associated metabolism. On...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9677
更新日期:2019-01-01 00:00:00
abstract::Ovarian cancer is the most malignant gynecologic neoplasm in women and has the worst prognosis of all cancer types in women based on the 5-year survival rates. A previous study indicated that mangiferin exerts an anti-neoplastic effect on human ovarian cancer cells by targeting Notch3. Additionally, it has been demons...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9708
更新日期:2019-01-01 00:00:00
abstract::Clinical effects of FOLFOX4 and TPF chemotherapy regimen on postoperative gastric cancer patients were investigated. A total of 60 patients admitted to the First People's Hospital of Changzhou receiving gastric cancer operation were selected and they were divided into two groups at random. Thirty patients in the FOLFO...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9695
更新日期:2019-01-01 00:00:00
abstract::Esophageal cancer staging is important for the treatment of esophageal cancer. Endoscopic ultrasonography (EUS) is a common diagnostic tool for esophageal cancer prior to surgery. However, EUS is unable to accurately discriminate the N-staging of lymph nodes. In order to distinguish an optimized standard for malignant...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9716
更新日期:2019-01-01 00:00:00
abstract::Increasing evidence has suggested that microRNAs (miRNAs; miRs) are extensively involved in the progression of chondrosarcoma (CHS). However, few studies have investigated the functional role of miR-525 in CHS tissues and cells. In the present study, it was discovered that miR-525 levels were decreased in CHS tissues ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9711
更新日期:2019-01-01 00:00:00
abstract::Downregulation of microRNA-34a (miR-34a) has frequently been observed in esophageal squamous cell carcinoma (ESCC). However, the underlying role and molecular mechanism of miR-34a in ESCC remains largely unknown. In the current study, it was demonstrated that miR-34a was downregulated and forkhead box M1 (FOXM1), a ta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9593
更新日期:2019-01-01 00:00:00
abstract::In the present study, the functions and mechanisms of rotundic acid (RA) underlying its induction of apoptosis in caspase-3-transfected MCF-7 human breast cancer cells (Cas3-MCF-7 cells) were investigated. RA induced apoptosis in Cas3-MCF-7 cells more efficiently compared with that in MCF-7 cells transfected with cont...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9616
更新日期:2019-01-01 00:00:00